Can antibiotics cause leukopenia (low white blood cells)? - Aspire Natural Health

Can antibiotics cause leukopenia (low white blood cells)?

I got a brief note from a friend recently telling me she had been in the hospital with a very low white blood cell count (WBC: meaning her blood had very few immune cells in it) and her doctors thought it was a reaction to the antibiotics they had given her.

So I did a consult with Dr. Google and Pubmed to have a better look at this. What I found was spotty information, but it is true that a good number of antibiotics can cause this to happen.

Figures I was able to get a hold of ranged from less than 1% to as high as 7% of people will suffer from low white blood cells after taking the drugs.  This can happen from as little as 5 days of antibiotics to more than 20 days.  And it takes anywhere from 3 days to 30 days to recover.

So, it can happen, but it’s not really common, and tends to happen with extended use of antibiotics. Yet another reason to use antibiotics carefully. They are wonderful drugs (perhaps the best thing that modern medicine has done) that have saved countless lives, but our abuse of them, has caused serious problems.

As a doctor specializing in the treatment of digestive issues, I’ve seen many people’s problems begin with a round of antibiotics.

Has this happened to you?

But more interesting to me was I could not find, despite some serious searching any explanation of how any of the antibiotics cause this to happen. How exactly do antibiotics cause low WBC counts?

Low white blood cells can happen for three basic reasons:

  1. Destruction / depletion of WBCs
  2. Decreased production by suppression of the bone marrow
  3. Sequestering of WBCs (meaning they are all ‘locked away’ in one place)

Which of these do antibiotics do (and I recognize that different ones may do different things)?

From what I could find, it seems we don’t know, and that weirds me out.

Why don’t we know? It seems worthwhile to know.

The answer of course, there’s no money in knowing, and it’s not a serious enough side effect for the government or other non-related entity to put up funding.

I did find one case report of a man who developed anti-neutrophil antibodies while on antibiotics (antibodies against one type of WBC) which then disappeared when he went off antibiotics.

So, I haven’t heard back from my friend beyond that first note but she did say she was going to go home soon. It looks like her WBCs should bounce back sometime between 3-30 days if she does nothing. I have to admit though I wouldn’t be comfortable doing nothing.

Here’s what I would do:

  1. Stay away from sick people – Kinda obvious, but your immunity is lower and your risk of getting sick much higher.
  2. Wash your hands – hands are the way we are exposed to most germs. And while I’m not anal about this in daily life (in the clinic is a different story) for at least a few days I would be aggressive about washing my hands.
  3. Probiotics – plenty of good bacteria to help prevent the risk of gut infections. Preferably continued for at least 30 days.  Click HERE for a blog post where I recommend some good brands you should take.
  4. Echinacea – as an “immune stimulant”.  Click HERE for a recommended brand.  Dosed aggressively, such as 1 tsp 6x day for the first 3 days, then backing off to 3-4 times a day for 1-2 weeks. Good echinacea should make your tongue tingle, if it doesn’t, it’s not going to help.
  5. Medicinal Mushroom blend – I like the medicinal mushrooms, especially as a chronic immune support. I like Natura’s Immucare and JHS’ medicinal mushroom products, like their 5 mushroom formula. Start with the Echinacea and continue for 1-2 months.

Of course, also eating a healthy appropriate diet, getting enough rest, some exercise and managing stress are also critical.


At Aspire Natural Health we are experts at helping people suffering with digestive issues and autoimmunity.

Are you looking for help?

Email us at or call us at 425-202-7849.  The first step of our process is to see if we’re a good fit for one another.  If we are, we’ll talk about next steps.  If not, that’s okay, and we’ll do our best to help you find the right person.

Everything is no-obligation and no-pressure, so you don’t have to worry.  You have nothing to lose!

Call us at 425-202-7849 or email us now

Photo attribution:

Another interesting post:

Can an elimination diet hurt me?