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Natural Biofilm Busters – Link
Biofilms protect bacteria from anti-microbial agents (drugs & herbs). Are there natural compounds that are biofilm disruptors? “Klebsiella pneumoniae…exists as a biofilm in persistent infections and in-dwelling medical devices…Six natural compounds were tested for their inhibitory effects on bacterial growth and biofilm formation…The results show that reserpine followed by linoleic acid, were the most potent biofilm inhibitors. Reserpine, an efflux pump inhibitor was effective at biofilm inhibition at a concentration of 0.0156 mg/mL, 64-fold lower concentration than its MIC [where it inhibits bacterial growth]. Linoleic acid, an essential fatty acid [the “evil” omega-6 fatty acid in vegetable oils] was effective as a biofilm inhibitor at 0.0312 mg/mL, which is 32-fold lower than its MIC. Berberine, another plant derived antimicrobial, chitosan and eugenol had an MBIC value of 0.0635 mg/mL. Curcumin, a natural phenolic compound was effective at biofilm inhibition at a concentration of 0.25 mg/mL, which is 50 fold less than its MIC.” So natural biofilm disruptors include: reserpine, linoleic acid, berberine, chitosan, eugenol [essential oil of clove] and curcumin [yay for turmeric!]
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