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Here are my comments and the links to three interesting and informative articles. I hope you enjoy. Please feel welcome to leave comments/questions below!
DrG – More on depression and T3. Patients who had already not benefited from 2 different antidepressants were given either lithium or T3. “A total of 142 adult outpatients with nonpsychotic major depressive disorder who had not achieved remission [with 2 different antidepressants]…were randomly assigned to augmentation with lithium (up to 900 mg/day; N=69) or with T(3) (up to 50 mug/day; N=73) for up to 14 weeks. The primary outcome measure was whether participants achieved remission…remission rates were 15.9% with lithium augmentation and 24.7% with T(3) augmentation, although the difference between treatments was not statistically significant. Lithium was more frequently associated with side effects…and more participants in the lithium group left treatment because of side effects…” Given the lower incidence of side effects and increased effectiveness (though we have to note that it wasn’t statistically significant meaning it may have been just chance that caused the greater benefit), if you’ve tried other antidepressants without benefit, consider adding T3 to your regimen.
DrG – How much protein do you need? It depends. How active are you? How inflamed are you? “Protein requirement in healthy young and old individuals is traditionally defined as the lowest protein intake sufficient to achieve neutral body protein balance. This concept, however, cannot be applied to those conditions characterized by unavoidable protein catabolism [breakdown] despite optimal nutrition, such as inactivity and diseases associated with systemic inflammation…The ability of dietary proteins to promote protein anabolism [building] is reduced by inactivity and inflammatory mediators, whereas physical exercise ameliorates the efficiency in using dietary proteins. Consequently, the protein intake level associated with the lowest rate of catabolism in inactivity and/or inflammation is greater than the minimum protein intake required to achieve neutral protein balance in healthy, physically active individuals. A protein intake of 1.2 g.kg.day is currently recommended for inactive healthy individuals, whereas guidelines recommend up to 1.5 g.kg.day in patients with severe systemic inflammation, such as those affected by critical illness or cancer.” So, if you do not exercise, you actually need MORE protein than if you exercise. if you have significant inflammation you need EVEN MORE protein.
So, a 150lbs healthy exercising person needs about 55 grams of protein (an ounce of meat or an egg contains about 7 grams of protein; so a non-grain, non-legume eating person would need to eat about 8 ounces of meat and/or eggs a day). A 150lbs sedentary person would need to up that to 82 grams of protein (11-12 ounces of meat/eggs), and a 150lbs person with significant inflammation would need around 102 grams of protein (14-15 ounces).
DrG – Biofilms are a huge problem and the reason for chronic infections. Biofilms allow bacteria to hide from antibiotics. There are substances that break down biofilms and this study shows that a bacteria known as Bacillus subtilis makes it’s own biofilm disruptors. “The extracellular α-amylase enzyme from Bacillus subtilis…was proved as an antibiofilm agent against methicillin-resistant Staphylococcus aureus (MRSA)…Vibrio cholerae [cholera]…and Pseudomonas aeruginosa…the crude enzyme caused 51.81-73.07% of biofilm inhibition. Beyond the inhibition, the enzyme was also effective in degradation of preformed mature biofilm…This study, for the first time, proved that α-amylase enzyme alone can be used to inhibit/disrupt the biofilms of V. cholerae and MRSA strains and beholds much promise in clinical applications.” So for anyone dealing with biofilms, it looks like a probiotic containing B subtilis should be part of the protocol.
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